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Experimental myringoplasty.

L Feenstra, B W van der Ven, F E Kohn

    The International Journal of Artificial Organs
    |November 1, 1980
    PubMed
    Summary
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    Researchers tested artificial eardrums made from biodegradable polymers and microporous membranes in rats. Poly(beta-benzyl-L-aspartate-co-L-leucine) showed the least reaction, forming the best new eardrums, while PTFE membranes supported reinforced tympanic membranes.

    Area of Science:

    • Biomaterials Science
    • Tissue Engineering
    • Otolaryngology

    Background:

    • Tympanic membrane perforations are common, necessitating effective repair strategies.
    • Current treatments often involve autografts or synthetic materials with varying success rates.
    • Developing biocompatible and bioresorbable materials for eardrum reconstruction is crucial.

    Purpose of the Study:

    • To evaluate the biocompatibility and tissue integration of novel artificial eardrum materials in a rat model.
    • To compare the host tissue response to biodegradable polymers and microporous membranes for eardrum regeneration.
    • To identify optimal materials for the development of functional and durable artificial tympanic membranes.

    Main Methods:

    • Surgical implantation of artificial eardrum materials (biodegradable polymers and microporous membranes) into the middle ear and subcutaneously in rats.

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  • Histological examination of explanted tissues at various time points up to one year.
  • Assessment of tissue ingrowth, inflammatory response, and structural integrity of the regenerated tympanic membranes.

    • Main Results:

    • Poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50 elicited minimal tissue reaction among the tested biodegradable polymers.
    • The poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50 implants resulted in newly formed tympanic membranes with superior thickness and integrity.
    • Microporous poly(tetrafluoroethylene) membranes served as effective scaffolds, promoting the formation of reinforced tympanic membranes.

    Conclusions:

    • Biodegradable poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50 is a promising material for artificial eardrum applications due to its low tissue reactivity and ability to support neotympanic membrane formation.
    • Microporous poly(tetrafluoroethylene) membranes offer a viable option as supportive structures for enhanced tympanic membrane repair.
    • These findings contribute to the advancement of biomaterials for otological reconstructive surgery.