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Related Experiment Videos

Malignant acanthosis nigricans: a review.

D S Rigel, M I Jacobs

    The Journal of Dermatologic Surgery and Oncology
    |November 1, 1980
    PubMed
    Summary

    Malignant acanthosis nigricans is a skin condition indicating underlying cancer. This review found gastric cancer in over 55% of cases, highlighting the need for prompt cancer screening.

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    Area of Science:

    • Dermatology
    • Oncology

    Background:

    • Malignant acanthosis nigricans presents as epidermal hyperplasia, typically in flexural areas.
    • This dermatosis is a recognized sign of an underlying malignancy.

    Purpose of the Study:

    • To review the association between malignant acanthosis nigricans and various cancers.
    • To discuss current theories on the pathogenesis of this condition.

    Main Methods:

    • Review of 277 cases of malignant acanthosis nigricans.
    • Analysis of the distribution of associated malignancies.

    Main Results:

    • Gastric carcinomas were associated in 55.5% of cases.
    • Other intra-abdominal carcinomas accounted for 17.7%.
    • Malignancies in other sites were present in 26.8%.

    Conclusions:

    • Malignant acanthosis nigricans is strongly linked to internal malignancies, particularly gastric cancer.
    • The findings underscore the importance of investigating for cancer in patients presenting with this dermatosis.

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