Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous opioids and social behavior.

J Panksepp, B H Herman, T Vilberg

    Neuroscience and Biobehavioral Reviews
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Defining the Clinical Target Volume in Postoperative Thymic Epithelial Tumours - A Clinical Practice Guide for UK Clinical Oncologists.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2025
    Same author

    Improved survival prediction for oropharyngeal cancer beyond TNMv8.

    Oral oncology·2021
    Same author

    Barriers and facilitators to health visiting teams delivering oral health promotion to families of young children: a mixed methods study with vignettes.

    Community dental health·2020
    Same author

    Evaluation of diagnostic and prognostic significance of Ki-67 index in pulmonary carcinoid tumours.

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2016
    Same author

    Physicians' Perceptions of Using Physical Education for Managing Childhood Obesity.

    The Physician and sportsmedicine·2016
    Same author

    Remote sensing in environmental police investigations: aerial platforms and an innovative application of thermography to detect several illegal activities.

    Environmental monitoring and assessment·2014
    Same journal

    Efficacy of Non-Invasive Brain Stimulation in Alzheimer's Disease: An Umbrella Review of Meta-Analyses.

    Neuroscience and biobehavioral reviews·2026
    Same journal

    Rhythms of interaction - the timescales of social coordination and why they matter.

    Neuroscience and biobehavioral reviews·2026
    Same journal

    Neural Bases of Memory Development: Insights from Magnetic Resonance Imaging.

    Neuroscience and biobehavioral reviews·2026
    Same journal

    Regional Heterogeneity of Brain Insulin Resistance: From Molecular Pathways to Neural Circuits.

    Neuroscience and biobehavioral reviews·2026
    Same journal

    Peripheral nervous system involvement in Parkinson's disease: Peripheral neuropathy, neuromuscular junction dysfunction, and clinical implications.

    Neuroscience and biobehavioral reviews·2026
    Same journal

    Violence on the self: Exploring the intersection of trauma and identity among sexual and gender minorities from a neurobiological and developmental perspective to advance our understanding of PTSD, moral injury, and dissociation symptoms.

    Neuroscience and biobehavioral reviews·2026
    See all related articles

    Brain opioids significantly influence social behaviors and emotions. Opioids reduce distress vocalizations and alter social interactions, while antagonists can increase distress, suggesting a key role in social attachment.

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Psychopharmacology

    Background:

    • Social attachment and affect are crucial for survival and well-being.
    • The role of endogenous opioids in modulating social behaviors is an area of ongoing research.
    • Previous studies suggest a link between opioid systems and social separation distress.

    Purpose of the Study:

    • To review and synthesize evidence supporting the hypothesis that brain opioids mediate social affect and attachments.
    • To examine the effects of opiates and opioid antagonists on specific social behaviors in animal models.

    Main Methods:

    • Review of existing literature on opioid administration and social behaviors.
    • Analysis of studies using opiates (e.g., morphine) and opioid antagonists (e.g., naloxone) in various animal models (puppies, guinea pigs, chicks, rodents).

    Related Experiment Videos

  • Observation and measurement of social behaviors such as distress vocalizations, proximity maintenance, play, maternal aggression, pup retrieval, and social learning.

    • Main Results:

    • Opiates effectively reduce social separation-induced distress vocalizations across species.
    • Morphine administration in rodents decreased proximity maintenance, increased play, and reduced maternal aggression, but did not affect pup retrieval.
    • Naloxone disrupted pup retrieval and reduced play, with no consistent effect on proximity maintenance.

    Conclusions:

    • Brain opioid systems play a significant role in modulating social emotions and behaviors.
    • Opioid pathways are involved in regulating social distress and attachment behaviors.
    • Further research into the neurobiological underpinnings of social behavior is warranted.