Ganglionic blocking effect of indomethacin and other prostaglandin synthetase inhibitors

The effect of various prostaglandin (PG) synthetase inhibitors such as indomethacin, diclofenac, fenoprofen, niflumic acid and sulindac was studied on the isolated sympathetic ganglion of Rana esculenta. It was found that all the tested drugs inhibited synaptic transmission, an effect related to the inhibition of PG synthetase. It has been suggested that PGF2a might be involved in the modulation of synaptic function in the frog sympathetic ganglion.