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Related Experiment Videos

Opiates and the gastrointestinal tract.

S J Konturek

    The American Journal of Gastroenterology
    |September 1, 1980
    PubMed
    Summary

    Endogenous opiates, like encephalins and endorphins, are found in the digestive system and influence gut motility and secretion. Their effects are reversed by opiate receptor antagonists, suggesting a role in gastrointestinal function.

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    Area of Science:

    • Gastroenterology
    • Neuroendocrinology
    • Pharmacology

    Background:

    • Opiate peptides (encephalins, endorphins) are present in the brain and have been detected in the digestive system.
    • These peptides are localized in gastrointestinal endocrine cells and nerve fibers.

    Purpose of the Study:

    • To investigate the physiological role of endogenous opiates in the digestive system.
    • To understand the effects of endogenous opiates on gastrointestinal motility and secretion.

    Main Methods:

    • Immunocytochemistry and radioimmunoassay were used to detect and localize opiate peptides.
    • The effects of endogenous opiates on gastrointestinal functions were observed.
    • Opiate receptor antagonists (e.g., naloxone) were used to assess receptor involvement.

    Main Results:

    • Endogenous opiates significantly affect gastrointestinal motility, including gastric emptying and intestinal transit.
    • They increase gastric secretion and mucosal microcirculation but do not affect gastrin release.
    • Pancreatic secretion is inhibited, likely due to suppressed intestinal hormone release (secretin, cholecystokinin).

    Conclusions:

    • Endogenous opiates play a significant role in regulating digestive system functions, particularly motility and secretion.
    • The observed effects are mediated through specific opiate receptors, as evidenced by reversal with antagonists like naloxone.

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