Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant
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Hearing Research
|March 1, 1981
Abstract:
S-2 (3-aminopropylamino)ethylphosphorothioate ameliorates hearing losses due to ototoxic doses of kanamycin sulfate in the guinea pig when administered one hour before the antibiotic. Since this radioprotectant is believed to operate as a free-radical scavenger, kanamycin ototoxicity may involve free radicals.