[Comparative study of cefotaxime serum and lung concentrations in 6 patients with thoracotomy (author's transl)]

This study was performed on samples obtained from 6 patients undergoing pulmonary surgery. Cefotaxime was administered by the i.m. route at a dose of 1 g twice daily and assays were performed on simultaneously obtained lung biopsies and serum. The comparison of tissue levels to the peak serum concentrations obtained at 30 minutes after injection provided evidence of the excellent tissue penetration of this cephalosporin in the human lungs.