[Clinical experience of cefotaxime (author's transl)]

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Published on: December 10, 2016

H Portier, C Carbon, Y Boussougant

    La Nouvelle Presse Medicale
    |February 26, 1981
    PubMed

    Insights

    Cefotaxime effectively treated various bacterial infections, including septicaemia, urinary tract, and pulmonary infections, with an 85.7% cure rate. This antibiotic demonstrated excellent tolerance, even in monotherapy for Gram-negative bacterial infections.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Bacteriology

    Context:

    • Bacterial infections pose a significant global health challenge.
    • Enterobacteriaceae are common causative agents of various infections.
    • Antibiotic resistance, particularly beta-lactamase production, complicates treatment.

    Purpose:

    • To evaluate the efficacy and safety of cefotaxime in treating diverse bacterial infections.
    • To assess cefotaxime's effectiveness against Gram-negative bacteria, including beta-lactamase producers.
    • To determine optimal dosage and administration routes for cefotaxime therapy.

    Summary:

    • A study treated 57 patients with cefotaxime for infections like septicaemia, UTIs, and pulmonary infections, achieving an 85.7% cure rate.
    • Pathogens included E. coli, Klebsiella, and Proteus, with most susceptible to cefotaxime (MIC ≤ 1 mcg/ml).
    • Cure rates varied by infection type (80-91.6%), with 68.4% success in beta-lactamase producing infections. Mean dosage was 45-50 mg/kg/day.

    Impact:

    • Cefotaxime is a well-tolerated and highly effective antibiotic for bacterial infections.
    • Demonstrates utility in monotherapy and prolonged treatment regimens.
    • Offers a viable option against infections caused by Gram-negative bacteria.

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