Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Outward currents in developing Drosophila flight muscle.

L Salkoff, R Wyman

    Science (New York, N.Y.)
    |April 24, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    K+ and Cl- channels and transporters in sperm function.

    Current topics in developmental biology·2013
    Same author

    Potassium channels in C. elegans.

    WormBook : the online review of C. elegans biology·2007
    Same author

    Dissection of K+ currents in Caenorhabditis elegans muscle cells by genetics and RNA interference.

    Proceedings of the National Academy of Sciences of the United States of America·2003
    Same author

    SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.

    Neuron·2001
    Same author

    Evolution tunes the excitability of individual neurons.

    Neuroscience·2001
    Same author

    Mutants of a temperature-sensitive two-P domain potassium channel.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2000

    During development, Drosophila flight muscle first expresses A current potassium channels, followed by delayed rectification and inward current channels. This developmental sequence aids in studying genetic factors influencing A current channels.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Ion Channel Physiology

    Background:

    • Voltage-sensitive potassium channels are crucial for neuronal excitability.
    • Understanding the developmental emergence of ion channels is key to grasping muscle function.
    • Drosophila flight muscle offers a model system for studying ion channel development.

    Purpose of the Study:

    • To investigate the developmental timeline of different voltage-sensitive potassium channels in Drosophila flight muscle.
    • To identify the sequence of appearance for A current, delayed rectification, and inward current channels.
    • To establish the utility of the A current channel as a model for genetic studies.

    Main Methods:

    • Utilized voltage clamp techniques to record ionic currents in developing Drosophila flight muscle.

    Related Experiment Videos

  • Analyzed the temporal expression patterns of distinct potassium channel types during development.

    • Main Results:

    • Initially, no active potassium channels are present in the developing muscle membrane.
    • A current channels, responsible for rapid, inactivating potassium currents, are the first to appear.
    • Channels mediating delayed rectification and inward currents emerge later in development, after A current channels.

    Conclusions:

    • The developmental emergence of voltage-sensitive potassium channels in Drosophila flight muscle follows a specific sequence.
    • The early and isolated expression of A current channels makes them ideal for investigating genetic determinants.
    • This study provides a foundation for future research into the genetic control of ion channel development and function.