[Manometric effects of metopimazine on the lower esophageal sphincter (author's transl)]

The effects of metopimazine on gastric, jejunal and colonic motility were recently described. The purpose of this study is to evaluate the action of a bolus injection of metopimazine (10 mg IV) on lower esophageal sphincter pressure with continuously perfused catheters. Significative increase (p less than 0,05) of lower esophageal sphincter pressure is always observed in 10 normal subjects and 5 patients with symptomatic gastro-esophageal reflux. The rate of lower esophageal sphincter pressure increase is significantly (p less than 0,05) more important in the symptomatic patients (160 +/- 19) than in controls (134 +/- 20). Further clinical study will be required to confirm these first data before proposing metopimazine as treatment of lower esophageal sphincter incompetence with gastro-oesophageal reflux.