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Related Experiment Videos

Biochemical markers for Huntington's chorea.

D R McLean, T Nihei

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |November 1, 1980
    PubMed
    Summary

    Platelets from Huntington's chorea patients show significantly higher dopamine uptake compared to healthy individuals. This study confirms previous findings but could not verify altered erythrocyte ATPase activity in these patients.

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    Area of Science:

    • Neuroscience
    • Biochemistry
    • Genetics

    Background:

    • Huntington's chorea (H.C.) is a neurodegenerative disorder.
    • Altered neurotransmitter systems are implicated in H.C. pathogenesis.
    • Previous studies suggested abnormal dopamine (DA) metabolism in H.C.

    Purpose of the Study:

    • To investigate dopamine uptake in platelets of H.C. patients.
    • To confirm previous findings on enhanced DA uptake in H.C. platelets.
    • To explore potential alterations in erythrocyte Na+ - K+ ATPase activity in H.C.

    Main Methods:

    • Assay of dopamine uptake in platelet-rich plasma from 11 H.C. patients.
    • Comparison of DA uptake levels with normal control subjects.
    • Measurement of Na+ - K+ ATPase activity in erythrocyte ghosts.

    Main Results:

    • Platelets from H.C. patients exhibited a 50% higher equilibrium dopamine uptake than controls at 0.11 mM DA.
    • The enhanced dopamine uptake in H.C. platelets was confirmed.
    • Attempts to verify increased Na+ - K+ ATPase activity in H.C. erythrocyte ghosts were unsuccessful.

    Conclusions:

    • Platelet dopamine uptake is a potentially useful biomarker for Huntington's chorea.
    • The mechanism behind enhanced DA uptake in H.C. warrants further investigation.
    • Na+ - K+ ATPase activity in erythrocytes does not appear to be directly linked to H.C. in this study.

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