Streptozotocin nephrotoxicity: studies on the defect in renal tubular acidification

A 64-year-old man developed hyperchloremic acidosis while being treated with streptozotocin for an unresectable hepatoma. Studies done during acid and alkali loading suggested that the defect in urinary acidification resided in the proximal tubule and thus represented a Type II or proximal renal tubular acidosis (RTA).