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[Drug therapy of chronic tissue ischemia with improvement of microcirculation]
Insights
Pentoxifylline (Trental) effectively improves microcirculation in patients with chronic ischemia when surgery is not an option. This study details its administration and positive effects on circulation, recommending it for various pathological tissue conditions.
Area of Science:
- Vascular Medicine
- Pharmacology
Context:
- Chronic ischemia presents significant challenges in patients unsuitable for surgical intervention.
- Microcirculatory dysfunction is a key factor in the progression of ischemic diseases.
Purpose:
- To evaluate the efficacy of Pentoxifylline (Trental) in improving microcirculation in patients with chronic ischemia.
- To analyze the administration, side effects, and vasoactive effects of Pentoxifylline at the microcirculatory level.
Summary:
- The study involved 213 patients with chronic ischemia, including those with arterial and venous circulation issues, and post-transplant patients.
- Pentoxifylline was administered, and its effects on microcirculation, particularly in pathologically altered tissues, were observed.
- The drug demonstrated vasoactive properties impacting microcirculatory perfusion.
Impact:
- Pentoxifylline can be a valuable therapeutic option for managing chronic ischemia and improving tissue perfusion.
- Findings support the use of Pentoxifylline in diverse conditions characterized by pathological circulatory alterations.
Abstract:
In this study the experience in treating 213 patients suffering from chronic ischemia with improvement of the microcirculation has been discussed. Medicamental treatment of chronic ischemia in patients with various pathologiic alterations of the circulation is indicated in cases which do not indicate reconstructive surgery. In the abundance of measures adopted in the treatment of these pathologic conditions the authors summarize their experience with the use of Pentoxyphyllin (Trental). During 1976 theyy treated 213 patients with this drug: 142 patients with pathologically altereed arterial circulation 51 patients with pathologically altered venous circulation 20 patienst on whom transplantations using various tissue transplants were used. The plan of administration of the drug, its undesireable side effects and the manifesting vasoactive effects of trental at the microcirculatory level especially on the microcirculation in tissue with pathologicaly altered perfusions has been discussed. Based on the shortlasting and limeted experiences the authors conclude that this drug can be recommended in therapy for various conditions of pathologicaly altered tissues circulation.