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Related Experiment Videos

Epidermal growth factor receptors.

E D Adamson, A R Rees

    Molecular and Cellular Biochemistry
    |February 11, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Epidermal Growth Factor Receptors (EGF-Rs) bind EGF, but receptor number doesn't dictate cell response. A new model is proposed, challenging the direct link between EGF-R internalization and mitogenic activation.

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    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Biochemistry

    Background:

    • Epidermal Growth Factor Receptors (EGF-Rs) are widely distributed cell membrane glycoproteins.
    • Their exact molecular weight is estimated at 170-190,000 mol. wt., though not fully characterized.
    • EGF binds to these receptors with high affinity (KA ~5 X 10(9) M-1).

    Purpose of the Study:

    • To review current data on EGF-R binding, affinity, and modulation.
    • To investigate the mechanism of action of EGF on cells.
    • To propose a new model for EGF-R function that accommodates existing evidence.

    Main Methods:

    • Literature review of studies on EGF-R characteristics and cellular responses.
    • Analysis of data correlating EGF binding, receptor clustering, internalization, and mitogenic effects.

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  • Development and comparison of theoretical models for EGF-R mechanism of action.

    • Main Results:

    • EGF-R number and affinity vary, and do not solely determine cellular mitogenic response.
    • While EGF binding, clustering, and internalization are established, a direct causal link to mitogenesis is not consistently observed.
    • Existing theories, like endocytic activation, do not explain all observed phenomena.

    Conclusions:

    • The relationship between EGF-R modulation and cellular response is complex.
    • Current evidence suggests that the direct connection between EGF-R internalization and mitogenic response may not be universally applicable.
    • An alternative model is proposed to better explain the observed data regarding EGF-R signaling.