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Related Experiment Videos

Hypothalamic catecholamine levels in dogs with spontaneous hyperadrenocorticism.

J C Meijer, R J Croughs, A Rijnberk

    Neuroendocrinology
    |April 1, 1981
    PubMed
    Summary

    Pituitary-dependent hyperadrenocorticism in dogs may involve low hypothalamic norepinephrine (NE) levels. Dopamine levels in the hypothalamus remained normal, suggesting it

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    Functional and morphological changes in the adenohypophysis of dogs with induced primary hypothyroidism: loss of TSH hypersecretion, hypersomatotropism, hypoprolactinemia, and pituitary enlargement with transdifferentiation.

    Domestic animal endocrinology·2008

    Area of Science:

    • Neuroendocrinology
    • Canine Endocrinology

    Background:

    • Hypercortisolism in dogs presents diagnostic challenges.
    • The role of hypothalamic neurotransmitters in hypercortisolism is not fully understood.

    Purpose of the Study:

    • To investigate hypothalamic norepinephrine (NE) and dopamine levels in dogs with spontaneous and iatrogenic hypercortisolism.
    • To determine if altered neurotransmitter levels correlate with specific forms of hypercortisolism.

    Main Methods:

    • Measurement of hypothalamic NE and dopamine content in dogs.
    • Comparison of neurotransmitter levels across groups: pituitary-dependent hyperadrenocorticism (PDH), adrenocortical tumor, corticotropin treatment, cortisone treatment, and healthy controls.

    Main Results:

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  • Subnormal hypothalamic NE concentrations were observed in 4 of 8 dogs with PDH.
  • Hypothalamic NE levels varied in dogs with adrenocortical tumors (subnormal, normal, or high).
  • Hypothalamic and striatal dopamine levels did not differ significantly among any of the studied groups.

    • Conclusions:

    • Subnormal hypothalamic NE may contribute to ACTH hypersecretion in canine PDH.
    • Normal hypothalamic dopamine levels in PDH dogs argue against a primary dopaminergic depletion as the cause of the disease.