[Membrane activity of canrenone in the normotensive subject: evaluation and significance]

Canrenone (100 mg per day) was given to ten young normotensive subjects during seven days. Plasma--K+ and erythrocytes--K+ (p less than 0,05), diuresis (+ 52%) and natriuresis (+ 70%) increased significantly during this time. Comparison between cations fluxes in erythrocytes before and after giving the drug showed an action on the membranal Na+ - K+ pump. This action site would complete well known anti-aldosterone properties.