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Related Experiment Videos

Rotavirus infection in foals.

M E Conner, R W Darlington

    American Journal of Veterinary Research
    |October 1, 1980
    PubMed
    Summary

    Rotavirus is a significant cause of foal diarrhea, confirmed by electron microscopy and experimental infection. Widespread antibodies in horses suggest this viral infection is common globally.

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    Area of Science:

    • Veterinary Virology
    • Equine Infectious Diseases

    Background:

    • Diarrhea in foals is a common and economically significant issue in equine health.
    • Rotavirus has been implicated in neonatal diarrhea in various animal species.

    Purpose of the Study:

    • To investigate the role of rotavirus in causing diarrhea in foals.
    • To determine the prevalence and distribution of rotavirus infection in foals.

    Main Methods:

    • Fecal samples from diarrheic foals were examined using electron microscopy.
    • Experimental infection was performed by inoculating a foal with rotavirus-containing filtrate.
    • Postmortem intestinal tissues were analyzed for viral replication.
    • Serological testing for rotavirus antibodies was conducted in horses from multiple regions.

    Main Results:

    • Rotavirus was detected in 30% of diarrheic foals examined.
    • Experimental inoculation successfully reproduced the disease.
    • Replicating rotavirus was identified in the intestinal epithelial cells of infected foals.
    • A high prevalence of antibodies to rotavirus was found in horses across different geographic locations.

    Conclusions:

    • Rotavirus is a major causative agent of diarrhea in foals.
    • The presence of antibodies indicates the widespread nature and ubiquitousness of rotavirus infection in horse populations.

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