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A new phenomenon (SMOG) associated with solid phase immune electron microscopy.

J D Almeida, L M Stannard, A S Shersby

    Journal of Virological Methods
    |January 1, 1980
    PubMed
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    Specific migration on the grid (SMOG) is a new phenomenon where virus particles move to form complexes with antibodies. This discovery offers a novel method for assessing antiserum properties and improving virus detection.

    Area of Science:

    • Virology
    • Immunology
    • Microscopy

    Background:

    • Solid phase immune electron microscopy (SPIEM) is a technique for studying virus-antibody interactions.
    • SPIEM offers speed and reagent economy in virological research.

    Purpose of the Study:

    • To investigate unexpected observations during SPIEM experiments.
    • To introduce and characterize a novel phenomenon termed specific migration on the grid (SMOG).

    Main Methods:

    • Utilizing solid phase immune electron microscopy (SPIEM).
    • Floating virus-coated grids on drops of specific antibody solutions.

    Main Results:

    • Virus particles were observed to migrate and form complexes with specific antibodies on the grid.

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  • This migration phenomenon was termed specific migration on the grid (SMOG).

    • Conclusions:

    • SMOG represents a newly identified interaction between viruses and antibodies.
    • SMOG has potential applications in assessing antiserum quality and enhancing virus detectability.
    • The underlying mechanism of SMOG requires further investigation.