Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proliferative diseases.

M B Sporn, E D Harris

    The American Journal of Medicine
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Excessive cell proliferation and matrix turnover drive diseases like cancer and fibrosis. Inhibiting proteinases and proliferative hormones offers new prevention strategies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Words, dictionaries, poems, and pictures.

    The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2003
    Same author

    One hundred ... and counting!

    The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2002
    Same author

    Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.

    Genome biology·2001
    Same author

    Making the best of a disturbed mind.

    The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2001
    Same author

    The bone and joint decade: a catalyst for progress.

    Arthritis and rheumatism·2001
    Same author

    Copper homeostasis: the role of cellular transporters.

    Nutrition reviews·2001
    Same journal

    Mineralocorticoid Antagonists for Post-MI HFpEF: Plausible Biology Meets Low Residual Risk?

    The American journal of medicine·2026
    Same journal

    GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

    The American journal of medicine·2026
    Same journal

    Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

    The American journal of medicine·2026
    Same journal

    Cave Canem - Beware of the Dog.

    The American journal of medicine·2026
    Same journal

    Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

    The American journal of medicine·2026
    Same journal

    Mesenteric panniculitis.

    The American journal of medicine·2026
    See all related articles

    Area of Science:

    • Biomedical Science
    • Pathogenesis Research
    • Pharmacology

    Background:

    • Cellular proliferation and extracellular matrix turnover are implicated in numerous diseases.
    • Understanding these processes is key to developing novel therapeutic interventions.

    Purpose of the Study:

    • To present a unifying concept linking cell proliferation and matrix turnover to disease pathogenesis.
    • To explore the roles of polypeptide hormones, collagen metabolism, and proteinases in disease.
    • To discuss the potential of inhibitors for disease prevention.

    Main Methods:

    • Conceptual review integrating existing knowledge on cellular and matrix dynamics.
    • Analysis of the roles of specific mediators like polypeptide hormones and proteinases.
    • Exploration of therapeutic targets, including enzyme inhibitors.

    Related Experiment Videos

    Main Results:

    • A unifying concept is proposed: excessive cell proliferation and matrix turnover are central to pathogenesis.
    • Polypeptide hormones and proteinases are identified as key mediators in disease initiation and progression.
    • Inhibitors of proteinases and proliferative hormones show potential for disease prevention.

    Conclusions:

    • Targeting specific proteolytic and proliferative mechanisms offers a unique opportunity for pharmacologic disease prevention.
    • This conceptual framework highlights the interconnectedness of cellular processes in disease.
    • Further research into these mechanisms can lead to innovative preventative therapies.