Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kynurenines and seizures.

I P Lapin

    Epilepsia
    |June 1, 1981
    PubMed
    Summary

    Kynurenines, tryptophan metabolites, can induce seizures in animal models. Taurine selectively counteracts these convulsant effects, suggesting a role for brain kynurenines in epilepsy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anxiogenic activity of quinolinic acid and kynurenine in the social interaction test in mice.

    Journal of psychopharmacology (Oxford, England)·2012
    Same author

    Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety.

    Advances in experimental medicine and biology·2004
    Same author

    [Drug side effect or negative placebo effect?].

    Eksperimental'naia i klinicheskaia farmakologiia·2000
    Same author

    [Anxiety models on mice: experimental evaluation and criticism of the method].

    Eksperimental'naia i klinicheskaia farmakologiia·2000
    Same author

    [Compliance - a decisive factor in physician-patient relations and treatment effectiveness].

    Klinicheskaia meditsina·2000
    Same author

    [Positive placebo effect in some mental and neurological disorders].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·1999

    Area of Science:

    • Neuroscience
    • Neurochemistry
    • Pharmacology

    Background:

    • Kynurenines are neuroactive metabolites derived from tryptophan.
    • These compounds have been implicated in various neurological processes.
    • Their role in seizure generation requires further elucidation.

    Purpose of the Study:

    • To review current data on the convulsant effects of kynurenines.
    • To investigate the interactions of kynurenines with other neurochemicals and drugs.
    • To explore the potential involvement of brain kynurenines in epilepsy.

    Main Methods:

    • Review of existing literature on kynurenine-induced seizures.
    • Experimental induction of myoclonic seizures in mice using l- and d,l-kynurenine.
    • Assessment of synergistic effects with strychnine.
    • Evaluation of antagonistic effects of taurine, glycine, and GABAergic agents.
    • Analysis of anticonvulsant drug effects on kynurenine- and quinolinic acid-induced seizures.

    Main Results:

    • l- and d,l-kynurenine induce hindleg myoclonic seizures in mice.
    • Both forms of kynurenine show selective synergism with strychnine.
    • Taurine selectively antagonizes l-kynurenine-induced seizures.
    • l-Glycine shows less selective antagonism, while GABA and muscimol are ineffective.
    • GABA derivatives and anticonvulsants differentially affect seizures induced by l-kynurenine and quinolinic acid.

    Conclusions:

    • Brain kynurenines possess convulsant properties.
    • Taurine demonstrates specific antagonism against kynurenine-induced seizures.
    • The differential effects of drugs suggest complex mechanisms.
    • Evidence supports the involvement of brain kynurenines in the development of epileptic seizures.

    Related Experiment Videos