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Possible link between converting enzyme inhibition and renomedullary interstitial cells
Federation Proceedings
|June 1, 1981
Summary
Renomedullary interstitial cells (RIC) are crucial for the kidney's antihypertensive function. Their deficiency, through absence, damage, or constraint, impairs blood pressure regulation and converting enzyme inhibitor effectiveness.
Area of Science:
- Nephrology
- Cardiovascular Physiology
Background:
- The kidney plays a dual role in blood pressure regulation, possessing both prohypertensive and antihypertensive functions.
- A key component of the kidney's antihypertensive role involves renomedullary interstitial cells (RIC), functioning in an endocrine manner.
Purpose of the Study:
- To explore the relationship between six experimental hypertension models and the antihypertensive function of RIC.
- To elucidate mechanisms by which RIC antihypertensive function can be compromised.
Main Methods:
- Review and analysis of six experimental models of hypertension.
- Examination of the impact of RIC integrity on the efficacy of converting enzyme inhibitors (CEI).
Main Results:
- RIC antihypertensive function can be deficient due to cell absence (renoprival state), severe damage (e.g., partial nephrectomy, malignant hypertension), or functional constraint (e.g., angiotensin-salt hypertension).
- CEI efficacy is lost when RIC are absent or damaged, but they remain effective in models with intact RIC.
- CEI may exert their antihypertensive effects, in part, through modulation of RIC function.
Conclusions:
- RIC are critical for mediating the kidney's antihypertensive function.
- Disruptions in RIC integrity or function represent significant mechanisms contributing to hypertension.
- RIC are a potential target for antihypertensive therapies, including CEI.