[A clinicopathologic study of ovarian tumors (author's transl)]

A clinicopathologic study was undertaken on 504 ovarian tumors which were treated in Osaka University Hospital during the past 18 years period. Also, marker substances were examined with some tumors. Most of the ovarian tumors were benign and cystic; 191 dermoid cysts, 106 serous cystadenomas, and 68 mucinous cystadenomas. Among the intermediate and malignant tumor groups, common epithelial tumors were the commonest and seen in older ages. Androblastomas, a granulosa cell tumor arising in dermoid cyst, and a possible juvenile granulosa cell tumor were rarely seen. Dysgerminomas and embryonal carcinomas were fairly popular in young ages. Malignant changes of dermoid cyst were rare and in older ages; the include an insular carcinoid, a strumal carcinoid, squamous cell carcinomas, an adenocarcinoma, and a malignant fibrous histiocytoma. Ovarian tumors in pregnancy were mostly dermoid cyst and fibroma. Bilaterality was more frequent in malignant tumors (20%) than others. The serum levels of marker substances have recently been utilized for the diagnosis, treatment and follow-up studies. Immunohistology was useful for the classification of some tumors. Radical operation and chemotherapy were chosen for the treatment of malignant ovarian tumors except some low grade malignancies, but the prognoses were generally poor.