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Human and animal togavirus antibodies in congenitally deformed infants

A P Cole, J E Banatvala, D Perry

    Journal of Medical Virology
    |January 1, 1981
    PubMed

    Insights

    Congenital malformations in infants were not linked to common viral infections. However, elevated immunoglobulin levels were observed in half of the affected infants, suggesting other immune system factors may be involved.

    Area of Science:

    • Virology
    • Immunology
    • Neonatal Medicine

    Background:

    • Congenital malformations can have diverse etiologies, including infectious agents.
    • Viral infections like Border disease, bovine virus diarrhoea, rubella, cytomegalovirus, and measles are potential concerns during pregnancy.

    Purpose of the Study:

    • To investigate the association between specific viral infections and congenital malformations in infants.
    • To assess immunoglobulin levels in infants with congenital malformations.

    Main Methods:

    • Cord blood samples from 30 congenitally malformed infants were screened for antibodies to Border disease virus, bovine virus diarrhoea virus, rubella, cytomegalovirus, and measles.
    • Total immunoglobulin levels were measured in affected infants and a control group.

    Main Results:

    • No serological evidence of Border disease virus, bovine virus diarrhoea virus, rubella, cytomegalovirus, or measles infection was found in the cord blood of malformed infants.
    • Elevated total immunoglobulin levels were detected in 15 out of 30 (50%) infants with congenital malformations.
    • None of the 35 infants in the control group showed significantly elevated immunoglobulin levels.

    Conclusions:

    • The studied viral infections are unlikely to be the primary cause of congenital malformations in this cohort.
    • Elevated immunoglobulin levels in infants with congenital malformations warrant further investigation into potential immune system dysregulation.

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