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Pathogenicity of Getah virus for mice
National Institute of Animal Health Quarterly
|January 1, 1981
Summary
Getah virus (GTV) pathogenicity in mice depends on age and inoculation route. Young mice experienced severe illness or death, while older mice showed no symptoms, indicating GTV
Area of Science:
- Veterinary Virology
- Pathogen Research
- Animal Models
Background:
- Getah virus (GTV) is an alphavirus known to cause disease in equids.
- Understanding GTV pathogenicity is crucial for disease management and prevention.
Purpose of the Study:
- To investigate the pathogenicity of the Sakai strain of Getah virus in mice.
- To determine the influence of host age and inoculation route on GTV disease severity.
Main Methods:
- Mice of different ages were inoculated intracerebrally with the Sakai strain of GTV.
- Viral replication and distribution were assessed in various organs.
- Horizontal and vertical transmission were observed.
Main Results:
- Pathogenicity was age-dependent; mice <9 days old died after intracerebral inoculation.
- Mice 11 days old exhibited growth retardation, paralysis, and sporadic death.
- Mice 13 days old showed no symptoms.
- GTV replicated extensively in organs, especially muscle tissue, of suckling mice.
- Horizontal transmission occurred among littermates, and vertical transmission via milk was confirmed.
Conclusions:
- Host age and inoculation route significantly impact GTV pathogenicity in mice.
- Suckling mice are highly susceptible to GTV, with widespread viral replication.
- GTV can be transmitted horizontally and vertically, posing a risk to offspring.