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A neuroheptapeptide influence on cognitive functioning in the elderly.

L H Miller, G A Groves, M J Bopp

    Peptides
    |January 1, 1980
    PubMed
    Summary

    The melanocyte-stimulating hormone/adrenocorticotropin (MSH/ACTH) heptapeptide improved visual retention in elderly subjects. This cognitive enhancement was more pronounced in men and showed no adverse effects, supporting earlier findings.

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    Area of Science:

    • Neuroscience
    • Gerontology
    • Pharmacology

    Background:

    • The shared heptapeptide core of melanocyte-stimulating hormone (MSH) and adrenocorticotropin (ACTH) is implicated in cognitive functions.
    • Previous studies indicated MSH administration enhances visual attention in men and rats.

    Purpose of the Study:

    • To investigate the effects of the MSH/ACTH heptapeptide on cognitive performance in elderly humans.
    • To assess potential differences in response between genders and evaluate safety.

    Main Methods:

    • A double-blind, cross-over study involving 13 elderly participants (9 men, 4 women).
    • Participants received a single 30 mg subcutaneous dose of the MSH/ACTH heptapeptide or saline.
    • Cognitive function was assessed using the Benton Visual Retention Test.

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    Main Results:

    • Significant improvement in Benton Visual Retention Test scores was observed after MSH/ACTH administration compared to saline.
    • The cognitive benefits appeared more substantial in male participants.
    • No adverse side effects or laboratory abnormalities were reported.

    Conclusions:

    • The MSH/ACTH heptapeptide demonstrates potential as a cognitive enhancer in the elderly population.
    • Findings extend previous research on MSH and visual attention to an older demographic.
    • The treatment was well-tolerated, suggesting a favorable safety profile.