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Related Experiment Video

Updated: Jul 6, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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Published on: February 16, 2016

Myocardial ischemia: detection and quantitation.

D D Waters, J S Forrester

Annals of Internal Medicine

|February 1, 1978

Summary

This summary is machine-generated.

Detecting myocardial ischemia, a late sign of coronary artery disease, is crucial. Early detection aids in preventing heart attack complications and evaluating treatment effectiveness.

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Area of Science:

Cardiology
Medical Diagnostics

Background:

Myocardial ischemia at rest is a late manifestation of coronary artery disease.
Transient ischemia can be induced by increased myocardial oxygen demand.
Physiologic abnormalities from ischemia are detectable through various assessments.

Purpose of the Study:

To highlight the clinical importance of detecting myocardial ischemia.
To discuss the challenges and significance of diagnosing ischemia in coronary artery disease.
To review methods for assessing ischemia and their role in evaluating therapies.

Main Methods:

Assessment of myocardial perfusion.
Evaluation of regional mechanical function.
Electrophysiology and metabolism studies.

Main Results:

Current methods for quantifying myocardial ischemia are imprecise.
Diagnostic tests vary in sensitivity, specificity, cost, and ease of use.
Despite limitations, methods have been used to evaluate therapies for reducing myocardial infarction size.

Conclusions:

Detecting myocardial ischemia is a critical clinical problem due to associated morbidity and mortality.
Coronary artery bypass surgery can reverse ischemia before permanent damage.
Accurate detection of ischemia is vital for guiding treatment and assessing therapeutic efficacy.