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Updated: Jul 6, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Myocardial ischemia: detection and quantitation

D D Waters, J S Forrester

    Annals of Internal Medicine
    |February 1, 1978
    PubMed

    Insights

    Detecting myocardial ischemia, a late sign of coronary artery disease, is crucial. Early detection aids in preventing heart attack complications and evaluating treatment effectiveness.

    Area of Science:

    • Cardiology
    • Medical Diagnostics

    Background:

    • Myocardial ischemia at rest is a late manifestation of coronary artery disease.
    • Transient ischemia can be induced by increased myocardial oxygen demand.
    • Physiologic abnormalities from ischemia are detectable through various assessments.

    Purpose of the Study:

    • To highlight the clinical importance of detecting myocardial ischemia.
    • To discuss the challenges and significance of diagnosing ischemia in coronary artery disease.
    • To review methods for assessing ischemia and their role in evaluating therapies.

    Main Methods:

    • Assessment of myocardial perfusion.
    • Evaluation of regional mechanical function.
    • Electrophysiology and metabolism studies.

    Main Results:

    • Current methods for quantifying myocardial ischemia are imprecise.
    • Diagnostic tests vary in sensitivity, specificity, cost, and ease of use.
    • Despite limitations, methods have been used to evaluate therapies for reducing myocardial infarction size.

    Conclusions:

    • Detecting myocardial ischemia is a critical clinical problem due to associated morbidity and mortality.
    • Coronary artery bypass surgery can reverse ischemia before permanent damage.
    • Accurate detection of ischemia is vital for guiding treatment and assessing therapeutic efficacy.

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