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Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice
Science (New York, N.Y.)
|July 31, 1981
Summary
Delta 9-tetrahydrocannabinol, a cannabinoid, affects testosterone levels in male mice. Low doses increase testosterone, while high doses decrease it, suggesting direct testicular influence.
Area of Science:
- Endocrinology
- Pharmacology
- Reproductive Biology
Background:
- Delta 9-tetrahydrocannabinol (THC) is the primary psychoactive component of cannabis.
- Cannabinoids are known to interact with the endocrine system.
- The effects of THC on male reproductive hormones require further elucidation.
Purpose of the Study:
- To investigate the impact of oral delta 9-tetrahydrocannabinol administration on plasma testosterone concentrations in male mice.
- To determine if THC influences testosterone levels independently of the pituitary gland.
- To explore the potential direct effects of THC on testicular steroidogenesis.
Main Methods:
- Oral administration of varying doses of delta 9-tetrahydrocannabinol to male mice.
- Measurement of plasma testosterone concentrations.
- Administration of gonadotropins (human chorionic gonadotropin) to assess THC interaction in hypophysectomized and intact mice.
Main Results:
- Oral delta 9-tetrahydrocannabinol exhibited a biphasic effect on testosterone levels: low doses caused sustained increases, while higher doses led to decreases.
- In mice treated with gonadotropins, delta 9-tetrahydrocannabinol administration resulted in maintained higher plasma testosterone concentrations.
- These findings suggest a direct influence of THC on testicular function.
Conclusions:
- Delta 9-tetrahydrocannabinol directly impacts testicular steroidogenesis in vivo.
- The cannabinoid may interact with gonadotropin signaling pathways.
- THC's dose-dependent effects on testosterone warrant further investigation in reproductive endocrinology.