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Related Experiment Videos

Calcifications in pituitary adenomas.

B Rilliet, G Mohr, F Robert

    Surgical Neurology
    |April 1, 1981
    PubMed
    Summary
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    Pituitary adenomas rarely show calcifications, particularly prolactinomas. These calcifications may be influenced by hormonal factors, especially in male patients.

    Area of Science:

    • Endocrinology
    • Neurosurgery
    • Pathology

    Background:

    • Pituitary adenomas are common tumors, but intratumoral calcifications are infrequent.
    • The incidence and significance of calcifications within pituitary adenomas require further investigation.

    Purpose of the Study:

    • To determine the incidence of intratumoral calcifications in pituitary adenomas.
    • To investigate the radiological and histological characteristics of these calcifications.
    • To explore potential correlations between calcifications and tumor type, patient demographics, and hormonal status.

    Main Methods:

    • Retrospective analysis of 755 surgically resected pituitary adenomas.
    • Microscopic examination for intratumoral calcifications.
    • Roentgenographic examination for radiologically visible calcifications.

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  • Histological assessment of calcification location and characteristics.

    • Main Results:

    • Intratumoral calcifications were found in 6.75% of cases microscopically and 1.72% radiologically.
    • Prolactinomas accounted for the majority (38/51) of calcified adenomas, with a higher incidence in males.
    • No correlation was observed between calcifications and age, sex, hormone levels, or tumor size.

    Conclusions:

    • Pituitary adenoma calcifications are rare, predominantly occurring in prolactinomas.
    • Calcifications are typically located within tumor tissue, not in degenerative areas.
    • Hormonal influences, possibly related to hyperprolactinemia, may play a role in calcification genesis.