Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Free radicals generation by the inflammatory cells.

G Zabucchi, P Bellavite, G Berton

    Agents and Actions. Supplements
    |January 1, 1980
    PubMed
    Summary

    Leukocytes dramatically increase oxygen consumption, producing reactive oxygen species during inflammation. This "respiratory burst" is crucial for immune cell functions like pathogen killing and tissue repair.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pleural mesothelioma and lung cancer: the role of asbestos exposure and genetic variants in selected iron metabolism and inflammation genes.

    Journal of toxicology and environmental health. Part A·2019
    Same author

    A genetic variant of NLRP1 gene is associated with asbestos body burden in patients with malignant pleural mesothelioma.

    Journal of toxicology and environmental health. Part A·2017
    Same author

    The true nature of salivary NGF.

    Oral diseases·2015
    Same author

    Editorial: Celebrating the 50th anniversary of the seminal discovery that the phagocyte respiratory burst enzyme is an NADPH oxidase.

    Journal of leukocyte biology·2014
    Same author

    Scientific criticism in homoeopathy: need to test more than disputes.

    International journal of clinical practice·2014
    Same author

    Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro.

    Allergy·2010

    Area of Science:

    • Immunology
    • Cellular Biology
    • Biochemistry

    Background:

    • Leukocytes exhibit dynamic oxidative metabolism changes during cellular functions.
    • Phagocytic challenges trigger a significant rise in oxygen consumption in granulocytes and mononuclear phagocytes.

    Purpose of the Study:

    • To investigate the mechanism and regulation of the leukocyte "respiratory burst".
    • To explore the role of reactive oxygen species in inflammatory processes.
    • To analyze the variability and reactivity of oxygen reduction products in different leukocyte types.

    Main Methods:

    • The study examines the biochemical pathways and cellular conditions leading to the respiratory burst.
    • It analyzes the production and reactivity of superoxide anion, hydrogen peroxide, and hydroxyl radical.
    • Comparative analysis of respiratory burst activity across different leukocyte populations.

    Main Results:

    • Leukocytes dramatically increase oxygen consumption and produce superoxide anion, hydrogen peroxide, and hydroxyl radical upon stimulation.
    • These reactive oxygen species are integral to micro-organism killing, tissue damage, and inflammatory amplification.
    • The study details the conditions inducing metabolic activation and the interrelationships of oxygen reduction products.

    Conclusions:

    • The respiratory burst is a key metabolic event in leukocytes, essential for inflammatory responses.
    • Understanding the production and reactivity of reactive oxygen species is critical for comprehending inflammation.
    • Variations in respiratory burst activity among leukocyte types influence their specific roles in immunity.

    Related Experiment Videos