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Splenic sequestration with sickle cell-C disease.

F Geola, S C Kukreja, S G Schade

Archives of Internal Medicine

|February 1, 1978

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Sickle cell-C disease can cause splenic hypersequestration, leading to severe anemia and enlarged spleen in adults. This rare complication was observed during pneumonia and pulmonary embolism events.

Area of Science:

Hematology
Internal Medicine
Pulmonology

Background:

Sickle cell-C hemoglobinopathy is a variant of sickle cell disease.
Adult patients with sickle cell hemoglobinopathies can experience splenic dysfunction.

Observation:

An adult male with sickle cell-C hemoglobinopathy presented with pneumonia and pulmonary thromboembolic events.
The patient developed severe anemia with rapidly increasing splenic size.

Findings:

Diminished splenic uptake of technetium Tc 99m sulfur colloid indicated reduced splenic function.
This was attributed to splenic hypersequestration, a rare phenomenon in adult sickle cell-C disease.

Implications:

Highlights a rare but severe complication of sickle cell-C disease in adults.

Related Experiment Videos

Underscores the importance of monitoring splenic function in these patients, especially during acute illness.

Suggests splenic hypersequestration as a potential cause of severe anemia in this population.