Clinical experience with cefotaxime (HR-756) in surgical patients

Area of Science:

• Infectious Diseases
• Pharmacology
• Clinical Medicine

Background:

• Surgical patients often develop diverse infections, including wound infections, septicaemia, and urinary tract infections.
• The emergence of antibiotic resistance necessitates evaluating the efficacy of parenteral antibiotics like cefotaxime.

Purpose of the Study:

• To assess the clinical and bacteriological efficacy of parentally-administered cefotaxime in adult surgical patients.
• To evaluate the systemic tolerance of cefotaxime in this patient population.

Main Methods:

• Twenty adult surgical patients with various infections received parenteral cefotaxime.
• Aetiological agents were identified, and antimicrobial susceptibility testing was performed using the agar dilution method.
• Clinical and bacteriological responses, along with systemic tolerance, were assessed.

Main Results:

• Cefotaxime demonstrated excellent clinical responses in 65% of patients and moderate responses in 10%.
• Bacteriological eradication was excellent in 70% of cases.
• Systemic tolerance was generally good, with only one patient experiencing adverse effects.

Conclusions:

• Parental cefotaxime is an effective and well-tolerated antibiotic for treating infections in adult surgical patients.
• The study supports the use of cefotaxime in managing a range of bacterial infections, including those caused by common Gram-negative organisms.