[Participation of cyclic nucleotides in immunogenesis and immune reactions of lymphocytes]

The paper deals with generalized literary and author's own data testifying to the role of cyclic nucleotides as mediators in the effect of specific and nonspecific factors on immunogenesis, from the proliferation of stem hemopoietic cell of bone marrow to the reaction of T and B lymphocytes to antigens. It is shown that changes in the system of lymphocytes cyclic nucleotides are most probably secondary in response to changes in intracellular concentration and distribution of calcium ions. Certain evidence is presented on immunopharmacological preparations based on cyclic nucleotides, their analogs and preparations modulating the activity of phosphodiesterases.