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Nitrate and nitrogen balances in men.

M S Kurzer, D H Calloway

    The American Journal of Clinical Nutrition
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Nitrate production in the body can explain some unexplained positive nitrogen balances in adults. This study investigated nitrate

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    Area of Science:

    • Human Nutrition
    • Metabolic Studies
    • Nitrogen Metabolism

    Background:

    • The Kjeldahl method, a traditional nitrogen analysis technique, does not detect nitrate.
    • Previous studies reported unexplained positive nitrogen balances in healthy adults.
    • The role of endogenous nitrate production in nitrogen balance was unclear.

    Purpose of the Study:

    • To determine if endogenous nitrate production contributes to positive nitrogen balances.
    • To quantify nitrate-nitrogen balance in humans under controlled dietary conditions.

    Main Methods:

    • Seven healthy men participated in a metabolic study.
    • Participants consumed five different diets over 9-day periods.
    • Nitrate and non-nitrate nitrogen intake and excretion were measured.

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    Main Results:

    • Nitrate-nitrogen excretion exceeded intake, indicating net synthesis.
    • Net nitrate synthesis was estimated to be around 100 mg/day.
    • Excess nitrate excretion accounted for 10-20% of previously unexplained positive nitrogen balances.

    Conclusions:

    • Endogenous nitrate production is a significant factor in nitrogen balance studies.
    • Nitrate excretion can explain a portion of positive nitrogen balances.
    • Further research is needed to fully elucidate nitrate's role in human metabolism.