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Effect of histamine on the spontaneous rosette formation
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1980
Summary
Hay fever patients showed a decrease in T lymphocytes when exposed to histamine. This suggests a potential link between histamine levels and T lymphocyte reduction in atopic individuals.
Area of Science:
- Immunology
- Allergy Research
Background:
- Hay fever is a common allergic condition.
- T lymphocytes play a crucial role in immune responses.
- Histamine is a key mediator in allergic reactions.
Purpose of the Study:
- To investigate the effect of histamine on T lymphocyte subpopulations in individuals with hay fever.
- To explore the potential correlation between histamine levels and T lymphocyte counts in atopic persons.
Main Methods:
- E rosette test used to evaluate T lymphocyte subpopulations.
- Lymphocytes from hay fever patients and healthy controls were exposed to varying histamine concentrations (10^-9 to 10^-4 M).
Main Results:
- A dose-dependent reduction in E rosette formation was observed with histamine concentrations between 2 x 10^-9 M and 2 x 10^-6 M.
- Higher histamine concentrations (10^-6 to 10^-4 M) resulted in both increased and decreased E rosette percentages.
Conclusions:
- Histamine exposure can modulate T lymphocyte subpopulations.
- Findings suggest a possible correlation between elevated histamine and decreased T lymphocytes in atopic individuals, warranting further investigation.