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[Myopathy and hypothyroidism].

J Ramírez Mayans, M Salas Alvarado, B Coutiño

    Boletin Medico Del Hospital Infantil De Mexico
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Hypothyroid children experience muscle weakness, hypotonicity, and enzyme level changes. These muscular disturbances are reversible with thyroglobulin therapy, showing no long-term impact on patient prognosis.

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    Area of Science:

    • Pediatric Endocrinology
    • Neuromuscular Disorders
    • Metabolic Myopathies

    Context:

    • Hypothyroidism in children can lead to significant neuromuscular manifestations.
    • Understanding these muscular disturbances is crucial for accurate diagnosis and management.
    • Thyroid hormone deficiency affects muscle structure and function.

    Purpose:

    • To detail the spectrum of muscular disturbances observed in hypothyroid children.
    • To investigate the reversibility of these muscular changes with treatment.
    • To assess the impact of these disturbances on the overall prognosis of pediatric hypothyroidism.

    Summary:

    • Hypothyroid children present with generalized proximal muscle weakness, hypotonicity, pseudohypertrophy, and delayed reflex relaxation.

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  • Elevated muscle enzymes (creatine phosphokinase and aldolase) and non-specific electromyographic findings are common.
  • Histopathological examination reveals a decrease in type II muscle fibers.

    • Impact:

    • Thyroglobulin therapy effectively reverses muscular disturbances in hypothyroid children.
    • These reversible neuromuscular changes do not negatively influence the long-term prognosis.
    • Early diagnosis and treatment are key to resolving muscle-related symptoms in pediatric hypothyroidism.