Two types of potassium channels in the PC12 cell line

Activation of K+ channels in the PC12 cell line was studied by comparing 86Rb+ efflux under depolarizing and non-depolarizing conditions. Evidence for both Ca2+-dependent and voltage-dependent K+ channels was obtained by studying depolarization-induced 86Rb+ efflux in solutions of varying Ca2+ concentration and in the presence of K+ and Ca2+ channel blocking agents.