[Improved pregnancy rates with ovulation stimulation using clomiphene and the effect of conjugated estrogens on the...

From a larger group of women treated which clomiphene 25 patients were selected who failed to conceive in spite of an indirect evidence of the ovulatory response and adequate luteal phase. Seventeen of them, who showed a distinct suppression of preovulatory reaction according to a modified cervical score, were treated with combined clomiphene and conjugated estrogens. The cervical score, the cycle pattern and the pregnancy rate were compared with the results of the previous treatment. The improvement of the cervical score was noted in 74.4% of patients, 6 women became pregnant, and the pregnancy rate related to the number of ovulatory cycles was 13.9%. Criteria for the treatment presented are discussed.