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Related Experiment Videos

Norepinephrine uptake in aging adrenergic nerve terminals.

D W Hoffman, M Marchi, E Giacobini

    Neurobiology of Aging
    |January 1, 1980
    PubMed
    Summary

    Aging reduces active norepinephrine (NE) uptake in chick irises, suggesting a loss of carrier-mediated transport or altered uptake characteristics in older birds.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Aging Research

    Background:

    • Norepinephrine (NE) is a crucial neurotransmitter involved in various physiological processes.
    • Nerve terminals in the chick iris are known to contain norepinephrine.
    • Understanding NE uptake mechanisms is vital for comprehending neuronal function and aging effects.

    Purpose of the Study:

    • To investigate the age-related changes in norepinephrine (NE) uptake in the chick iris.
    • To determine if active, carrier-mediated NE transport is affected by aging.
    • To explore alterations in the biochemical and pharmacological properties of NE uptake during senescence.

    Main Methods:

    • Utilizing radiolabeled 3H-NE to quantify uptake in adult and aging chick irises.
    • Assessing the dependence of NE uptake on sodium (Na+).
    • Evaluating the temperature-sensitivity and sensitivity to inhibitors like ouabain.

    Main Results:

    • Total accumulation of 3H-NE in the iris remained unchanged with age.
    • A significant decline in Na+-dependence of NE uptake was observed in aging chick irises.
    • Reduced temperature-sensitivity and sensitivity to ouabain and other inhibitors indicated impaired active transport.

    Conclusions:

    • Aging in chick irises is associated with a decline in active, carrier-mediated norepinephrine uptake.
    • The observed changes suggest either a loss of functional uptake carriers or modifications in their biochemical and pharmacological characteristics.
    • Age-related alterations in iris composition and NE accumulation sites may contribute to these findings.

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