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Related Experiment Videos

Gynecomastia with ketoconazole.

R DeFelice, D G Johnson, J N Galgiani

Antimicrobial Agents and Chemotherapy

|June 1, 1981

Summary

This summary is machine-generated.

Ketoconazole treatment caused bilateral gynecomastia in three men. Symptoms resolved even with ongoing medication, suggesting a direct drug effect on breast tissue.

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Area of Science:

Endocrinology
Pharmacology
Oncology

Background:

Ketoconazole is a broad-spectrum antifungal agent.
Gynecomastia is the enlargement of breast tissue in males.

Observation:

Three out of forty male patients developed bilateral gynecomastia during ketoconazole therapy.
The gynecomastia symptoms resolved spontaneously despite continued ketoconazole treatment.

Findings:

The observed gynecomastia appears to be a direct pharmacological effect of ketoconazole on breast tissue.
This suggests a potential endocrine-disrupting property of ketoconazole.

Implications:

Clinicians should be aware of the potential for ketoconazole-induced gynecomastia.
Further research may be warranted to elucidate the precise mechanism of this adverse effect.