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Related Experiment Videos

The insulin infusion test: a safe procedure?

B C De Vries, H C Holtkamp, P J Leeuwerik

    The British Journal of Surgery
    |February 1, 1978
    PubMed
    Summary

    Insulin infusion tests in peptic ulcer patients revealed cardiovascular changes like ectopic beats in 31%, particularly in older individuals. Continuous monitoring is crucial despite the test being safer than the Hollander test.

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    Area of Science:

    • Cardiology
    • Gastroenterology
    • Clinical Pharmacology

    Background:

    • Peptic ulcer disease and post-vagotomy states require diagnostic testing.
    • The Hollander insulin test is a conventional diagnostic method.
    • Cardiovascular safety during diagnostic testing is paramount.

    Purpose of the Study:

    • To evaluate the cardiovascular effects of the insulin infusion test in patients with peptic ulcer disease or after vagotomy.
    • To assess the relationship between ECG abnormalities and patient age, blood glucose, and serum potassium levels.
    • To compare the safety profile of the insulin infusion test with the conventional Hollander test.

    Main Methods:

    • 130 insulin infusion tests (0.05 u kg-1h-1) were performed in 87 patients.
    • Electrocardiogram (ECG) tracings were continuously monitored during the tests.
    • Blood samples were analyzed for glucose and potassium levels.

    Main Results:

    • Electrocardiographic changes occurred in 31% of tests, including supraventricular and ventricular ectopic beats, ST-T changes, and U waves.
    • Two tests showed potentially dangerous arrhythmias.
    • A significant correlation was observed between ECG abnormalities and patient age.
    • No significant relationship was found between ECG changes and glucose or potassium levels.

    Conclusions:

    • The insulin infusion test is likely safer than the conventional Hollander test for evaluating peptic ulcer patients.
    • Constant electrocardiographic monitoring is essential during the insulin infusion test.
    • Age is a significant factor associated with cardiovascular changes during this test.

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