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Related Experiment Videos

Initial clinical studies of vindesine.

M Valdivieso, S Richman, A M Burgess

    Cancer Treatment Reports
    |September 1, 1981
    PubMed
    Summary

    Vindesine, a vinca alkaloid derivative, showed tolerability in advanced cancer patients. Doses of 7.5-10 mg every two weeks were well-tolerated, with some patients responding even after vincristine therapy failure.

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    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Vindesine is a novel vinca alkaloid derivative.
    • Vinca alkaloids are known for their anti-cancer properties.

    Purpose of the Study:

    • To evaluate the safety and efficacy of vindesine in patients with advanced, refractory malignancies.
    • To determine dose-limiting toxicities and maximally tolerated doses of vindesine.

    Main Methods:

    • Phase I clinical trial involving 68 patients with advanced, refractory malignancies.
    • Administration of single total doses of vindesine ranging from 2 to 12.5 mg, repeated every 1-2 weeks.

    Main Results:

    • Dose-limiting toxicities included myelosuppression (neutropenia), gastrointestinal effects (constipation, paralytic ileus), and neurologic effects (peripheral neuropathy).
    • Doses of 7.5-10 mg (4-5 mg/m2) repeated every 2 weeks were well-tolerated.
    • Observed responses included partial remissions in acute leukemia and minor responses in renal cell carcinoma and squamous cell carcinomas.

    Conclusions:

    • Vindesine is generally well-tolerated in humans, sharing some toxicities with vinblastine and vincristine.
    • Efficacy in patients resistant to vincristine suggests a lack of clinical cross-resistance, indicating potential for vindesine in such cases.

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