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Neuropathy associated with chronic low level exposure to n-hexane
Clinical Toxicology
|May 1, 1981
Summary
Chronic exposure to n-hexane below the threshold limit value (TLV) can cause peripheral neuropathy. This case study suggests the current TLV for n-hexane may not be sufficiently protective against nerve damage.
Area of Science:
- Occupational Health
- Toxicology
- Neurology
Background:
- The established threshold limit value (TLV) for n-hexane is 500 ppm.
- Exposure to n-hexane concentrations exceeding the TLV is known to cause peripheral neuropathy.
Observation:
- A worker developed peripheral neuropathy with histologic findings characteristic of n-hexane toxicity.
- This occurred despite chronic occupational exposure to n-hexane at concentrations below 450 ppm.
Findings:
- Histologically confirmed peripheral neuropathy in a worker exposed to n-hexane below the current TLV.
- Demonstration of n-hexane toxicity at concentrations previously considered safe.
Implications:
- The current TLV for n-hexane may be inadequate to prevent peripheral neuropathy.
- Reevaluation of occupational exposure limits for n-hexane is warranted.
- Highlights the need for ongoing monitoring of workplace chemical safety.