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Related Experiment Videos

Transmitter-induced calcium current.

T C Pellmar

    Federation Proceedings
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Serotonin triggers a calcium ion current in Aplysia neurons, influencing neuronal activity. Cyclic AMP also induces a similar current, but the exact signaling pathway remains under investigation.

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    Regional differences in glial cell modulation of synaptic transmission.

    Hippocampus·1997

    Area of Science:

    • Neuroscience
    • Cellular Neuroscience

    Background:

    • Serotonin is a neurotransmitter known to modulate neuronal excitability.
    • Calcium ions play crucial roles in various neuronal functions, including synaptic transmission and signal transduction.

    Purpose of the Study:

    • To investigate the ionic mechanisms underlying the effects of serotonin on Aplysia neurons.
    • To explore the potential role of cyclic AMP in mediating serotonin's action.

    Main Methods:

    • Iontophoretic application of serotonin and cyclic AMP to Aplysia neurons.
    • Voltage-clamp recordings to measure ionic currents.
    • Pharmacological manipulation using channel blockers and enzyme inhibitors.

    Main Results:

    • Serotonin application induced a slow, voltage-dependent inward current carried by calcium ions.

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  • This response was insensitive to chloride and potassium concentration changes but affected by sodium and calcium levels.
  • Intracellular cyclic AMP also produced a similar inward current, suggesting a potential link, though pharmacological data indicated independent pathways.
  • Phosphodiesterase inhibitors potentiated both serotonin and cyclic AMP responses.

    • Conclusions:

    • Serotonin activates a calcium current in Aplysia neurons, contributing to neuronal signaling.
    • While cyclic AMP mimics this effect, the precise mediation mechanism requires further clarification.
    • The identified calcium current has significant implications for understanding neuronal communication and plasticity.