Neuroarthropathy (Charcot joints) in familial amyloid polyneuropathy

Two patients with familial amyloid polyneuropathy (FAP) of Andrade type developed neuroarthropathy (Charcot joints). In 1 patient both knees were affected and in the other patient both ankles. This complication added markedly to the already severe disability and limitation of movement caused by the underlying illness. To the best of our knowledge this is the first description of Charcot joints in FAP. Neuroarthropathy in FAP is probably more common than previously suspected and should be sought in any case of FAP with joint disease.