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Related Experiment Videos

Asthma caused by bromelin inhalation.

F Galleguillos, J C Rodriguez

    Clinical Allergy
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Bromelain, an enzyme in anti-inflammatory drugs, can cause bronchial asthma. Immediate allergic reactions to bromelain inhalation were confirmed by skin tests and blocked by sodium cromoglycate.

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    Area of Science:

    • Allergology
    • Pulmonology
    • Enzymology

    Background:

    • Bromelain is a proteolytic enzyme derived from pineapple, used for its anti-inflammatory properties in various medicinal applications.
    • Occupational asthma is a significant concern, often triggered by inhaled allergens in the workplace or through medicinal exposure.

    Observation:

    • Two cases of bronchial asthma are presented, linked to the inhalation of bromelain.
    • Patients exhibited immediate hypersensitivity reactions upon exposure to bromelain.

    Findings:

    • Skin prick tests with bromelain extract yielded positive results in both cases.
    • Inhalation challenge tests demonstrated immediate asthmatic responses.
    • These immediate reactions were effectively inhibited by sodium cromoglycate.

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  • Corticosteroids did not prevent the immediate asthmatic reactions induced by bromelain.

    • Implications:

    • This highlights bromelain as a potential occupational or medicinal allergen causing asthma.
    • The findings suggest a role for mast cell stabilization (e.g., with sodium cromoglycate) in managing acute bromelain-induced asthma.
    • Further investigation into the immunological mechanisms of bromelain hypersensitivity is warranted.