Related Experiment Videos
[Clinical experience with cefotiam in the field of pediatrics (author's transl)]
Insights
This clinical study evaluated cefotiam (CTM) in pediatric infections. CTM demonstrated effective clinical and bacteriological responses in most cases of urinary tract infections and other pediatric conditions.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Pharmacology
- Antimicrobial Therapy
Background:
- Assessing the efficacy and safety of cefotiam (CTM) in treating various pediatric infections.
- Evaluating CTM's clinical and bacteriological outcomes in a small cohort of pediatric patients.
Observation:
- The study included six pediatric cases: 2 urinary tract infections (UTIs), 1 vaginitis/vulvitis, 1 cervical lymphadenitis, and 1 thigh abscess/coxitis.
- Clinical responses were excellent in 3 patients and good in 1; one patient dropped out due to concurrent antibiotic use.
Findings:
- CTM successfully eradicated pathogens including E. coli, P. mirabilis, Staph. epidermidis, P. morganii, H. influenzae, Str. pneumoniae, and Staph. aureus.
- No significant adverse effects were noted, although one patient exhibited elevated liver enzymes (GOT, GPT) and LDH, with causality uncertain due to concomitant antibiotic use.
Implications:
- Cefotiam (CTM) shows promise as an effective antibiotic for treating a range of pediatric infections.
- Further investigation is warranted to confirm safety and efficacy in larger pediatric populations, particularly regarding potential liver enzyme elevations.
Abstract:
A clinical study on cefotiam (CTM) was performed in the field of pediatric infection, and the following results were obtained: The number of cases studied were six including 2 cases of U.T.I., 1 case of vaginitis and vulvitis, 1 cervical lymphadenitis, 1 absence of thigh and coxitis. Clinical responses to CTM were excellent in 3 cases, good in 1 cases but there was 1 exception who dropped out because of concurrent use of other antibiotics. As for bacteriological responses, CTM eliminated the pathogens E. coli and P. mirabilis from U.T.I., Staph. epidermidis and P. morganii, from vaginitis and vulvitis, H influenzae and Str. pneumoniae from cervical lymphadenitis and Staph. aureus from abscess of thigh. No side effect was observed except 1 case who showed an elevation of GOT, GPT and LDH. It is uncertain, however, wether this abnormality was resulted from the use of CTM or not, because the other antibiotics were used also.