[Subacute toxicity study of cefotiam in three-week old beagle puppies (author's transl)]

A subacute (5-week) subcutaneous toxicity study of cefotiam (CTM) was carried out using 9 three-week old Beagle puppies. The puppies were assigned to one of three groups, each containing three. Puppies in group I (control) were given physiological saline; puppies in group II and III were given 300 mg/kg/day of CTM and cefazolin (CEZ), respectively. No behavioral abnormalities were seen in puppies in each group. The changes, considered to be drug-related, were histopathological changes at the sites of injection, which consisted inflammatory cellular infiltration, hemorrhage and hyperplasia of fibroblast in connective tissue of skin and skeletal muscle. In terms of severity, CTM was rather more irritating than CEZ. Except the histopathological changes described above, there observed no abnormalities which were considered to be related to CTM.