Related Experiment Video

Updated: Sep 3, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
00:06

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Receptor dysfunctions in human disease

L H Block, W Tenschert, R Locher

    Klinische Wochenschrift
    |April 15, 1981
    PubMed

    Insights

    Characterizing hormone and drug binding to cell receptors offers insights into endocrine and metabolic disorders. Altered receptor function is linked to various diseases, including cancer and immune conditions.

    Area of Science:

    • Endocrinology and Metabolism
    • Cell Biology
    • Immunology

    Background:

    • Cellular receptors play a crucial role in mediating hormone and drug actions.
    • Dysregulation of cellular receptors is implicated in the pathogenesis of endocrine and metabolic disorders.
    • Receptor abnormalities include altered number, binding affinity, and autoantibody production.

    Purpose of the Study:

    • To explore the characterization of binding parameters of hormones and drugs to specific receptors.
    • To evaluate pathogenic mechanisms in endocrine and metabolic disorders through receptor analysis.
    • To understand the role of altered receptor physiology in various diseases.

    Main Methods:

    • Characterization of binding parameters.
    • Analysis of receptor number and binding affinity.
    • Detection of anti-receptor antibodies.

    Main Results:

    • Binding parameter characterization provides an approach for evaluating disease mechanisms.
    • Receptor dysregulation involves changes in receptor number and affinity.
    • Antibodies against receptor molecules can be produced.

    Conclusions:

    • Altered receptor physiology is valuable for understanding abnormalities in cellular recognition.
    • Receptor dysfunction contributes to neoplastic, inflammatory, immune, and developmental diseases.
    • Receptor binding studies are essential for comprehending complex cellular control mechanisms.

    More Related Videos

    Functional Characterization of Endogenously Expressed Human RYR1 Variants07:59

    Functional Characterization of Endogenously Expressed Human RYR1 Variants

    Published on: June 9, 2021

    Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies10:08

    Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

    Published on: July 20, 2022

    Related Concept Videos

    Intracellular Hormone Receptors01:08

    Intracellular Hormone Receptors

    Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
    Receptor Downregulation in MVBs01:15

    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
    Types of Receptors: Cell Surface Receptors01:28

    Types of Receptors: Cell Surface Receptors

    Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
    G Protein-coupled Receptors01:15

    G Protein-coupled Receptors

    G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
    GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
    Transducer Mechanism: G Protein–Coupled Receptors01:30

    Transducer Mechanism: G Protein–Coupled Receptors

    G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
    GPCRs are also called heptahelical, 7TM, or...
    Transducer Mechanism: Enzyme-Linked Receptors01:27

    Transducer Mechanism: Enzyme-Linked Receptors

    Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
    Major types that are helpful drug targets include: