Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunocomplexes and primary lung cancer.

L Lenzini, L Rottoli, P Sestini

    Allergologia Et Immunopathologia
    |March 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Meta-Analysis to Unveil the Diagnostic Gaps in Anderson-Fabry Disease in Women.

    Journal of inherited metabolic disease·2026
    Same author

    The effect of different structural decoration geometries on vibration propagation in spider orb webs.

    PloS one·2025
    Same author

    Status of QCD precision predictions for Drell-Yan rapidity distributions.

    The European physical journal. C, Particles and fields·2025
    Same author

    Asthma and allergies in schoolchildren: data from the European SINPHONIE study.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
    Same author

    Primary Aldosteronism and Drug Resistant Hypertension: A "Chicken-Egg" Story.

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2023
    Same author

    Letter of response to Nabi Z, Stansfeld J, Plöderl M, Wood L, Moncrieff J. Effects of lithium on suicide and suicidal behaviour: a systematic review and meta-analysis of randomised trials. <i>Epidemiol Psychiatr Sci</i>. 2022 Sep 16;31:e65. doi: 10.1017/S204579602200049X.

    Epidemiology and psychiatric sciences·2022
    Same journal

    Peach sublingual immunotherapy for lipid transfer protein syndrome.

    Allergologia et immunopathologia·2026
    Same journal

    Gastrointestinal stenosis: an underrecognized complication of CARMIL2 deficiency.

    Allergologia et immunopathologia·2026
    Same journal

    Peach sublingual immunotherapy for lipid transfer protein syndrome.

    Allergologia et immunopathologia·2026
    Same journal

    Vitamin B12 allergy and desensitization.

    Allergologia et immunopathologia·2026
    Same journal

    Chronic HBV infection, stemness pathways, and compromised immune surveillance in HCC development.

    Allergologia et immunopathologia·2026
    Same journal

    Application of FeNO in the diagnostic and therapeutic algorithm of pediatric asthma: From chronic cough and wheeze to personalized management.

    Allergologia et immunopathologia·2026
    See all related articles

    Circulating immune complexes (CIC) are prevalent in primary lung cancer (PLC) and increase with disease stage, particularly lymph node involvement. Their presence is linked to reduced 12-month survival rates in lung cancer patients.

    Area of Science:

    • Oncology
    • Immunology

    Background:

    • Circulating immune complexes (CIC) are implicated in various diseases.
    • Their role in primary lung cancer (PLC) requires further elucidation.

    Purpose of the Study:

    • To investigate the prevalence and clinical significance of CIC in primary lung cancer patients.
    • To analyze the association between CIC, clinical staging, and patient survival.

    Main Methods:

    • A horizontal study involving 71 primary lung cancer patients before treatment.
    • Precipitation technique using PEG to assay CIC, C1q, IgG, and IgM fractions.
    • Correlation analysis with clinical stage (TNM) and survival data.

    Main Results:

    • CIC were detected in 47% of patients, with higher frequency in advanced stages (Stage III).

    Related Experiment Videos

  • CIC prevalence significantly correlated with lymph node involvement (N stage) but not tumor size (T) or metastasis (M).
  • Elevated C1q and/or IgG fractions were observed in 40% of cases, with specific patterns associated with N1 and N2 stages.
  • Patients with CIC exhibited a significantly lower 12-month survival rate compared to those without.

    • Conclusions:

    • CIC are a significant finding in primary lung cancer, increasing with disease progression.
    • CIC presence, particularly specific fraction patterns, may serve as a prognostic biomarker.
    • The association of CIC with reduced survival highlights their potential role in lung cancer pathogenesis and prognosis.