[Mechanism of action of collagen on processes of regeneration]

The effect of collagen, its hydrolysate and glycin on metabolism of cyclic nucleotides in wound tissue was studied in experiments on animals. Collagen was found to reduce the cAMP level in muscles of the wound fundus, while the concentration of cGMP remained unchanged. Collagen hydrolysate induced unidirectional changes in cyclic nucleotides, whereas glycin opposite ones. The basal activity of cAMP phosphodiesterase was not changed. The mechanism of the stimulatory effect of collagen on wound healing is discussed.